纳洛酮联合血塞通治疗老年急性脑梗死疗效观察

Observation on the curative effect of using naloxone combined with Xuesaitong for treating elderly acute cerebral infarction

目的探讨纳洛酮联合血塞通治疗老年急性脑梗死患者临床疗效。方法 150例急性脑梗死患者随机分为观察组和对照组,各75例。均行常规治疗2周,观察组同时加用纳洛酮3.5mg联合血塞通0.5g静滴。在治疗前后测定神经功能缺损程度和血浆、脑脊液中阿片肽含量,进行疗效评估。结果治疗前两组患者血浆和脑脊液中阿片肽含量、神经功能缺损评分差异无统计学意义(P>0.05);治疗后观察组阿片肽含量、神经功能缺损评分均低于对照组(P<0.01)。观察组治疗有效率为94.7%,高于对照组的73.3%(P<0.01)。结论纳洛酮联合血塞通治疗老年急性脑梗死具有良好的临床疗效。

Objective To explore the clinical curative effect of using naloxone combined with Xuesaitong for treating elderly acute cerebral infarction.Methods One hundred and fifty patients with acute cerebral infarction were randomly divided into experimental group （GE,n=75） and control group （GC,n=75）,which got the normal treatment for 2 weeks. In addition,the patients in the experimental group received intravenous infusion with naloxone （trade name：Jin Erlun） 3.5 mg and Xuesaitong 0.5 g. The neurologic impairment and the opioid peptide content in plasma and CSF were detected before and after treatment and curative effect evaluation was carried out.Results There was no statistical difference in the scores of opioid peptide content in plasma and CSF and the neurologic impairment before and after treatment in the two groups （P0.05）. After treatment,the contents of opioid peptides in plasma and the neurologic impairment in GE were significantly lower than those of the GC（P0.01）.The curative effective power in GE was 94.7%,which was higher than that of the GC （73.3%） （P0.01）.Conclusion Naloxone combined with Xuesaitong is effective in treating elderly patients with acute cerebral infarction.