间歇与持续蓝光照射治疗新生儿黄疸临床疗效分析

Clinical constrast analysis of intermittent and continuous blue light irradiation treatment for neonatal jaundice

目的比较间歇蓝光照射与持续蓝光照射治疗新生儿黄疸的临床疗效及不良反应。方法将96例新生儿黄疸患者随机分为两组,各48例。均给予酶诱导剂、益生菌、抗感染等常规治疗。在此基础上,一组给予间歇蓝光照射(间歇照射组),另一组给予持续蓝光照射(持续照射组)。照射72h后,比较两组新生儿临床治疗有效率及不良反应的发生率。结果经照射72h后,两组治疗有效率无显著差异(P>0.05),间歇照射组不良反应发生率低于持续照射组(P<0.05)。结论间歇蓝光照射可达到与持续蓝光照射相同的治疗效果,且不良反应少,值得临床推广应用。

Objective To compare the clinical efficacy and adverse effects between intermittent and continuous blue light irradiation treatment for neonatal jaundice.Methods Ninety-six cases of neonatal jaundice were randomly divided into intermittent blue-ray-irradiation group（group I,n=48）and continuous blue-ray-irradiation group （group C,n=48）.Newborns of two groups were respectively given the conventional treatment with enzyme inducers,probiotics,anti-infection medicine. Group I was treated with intermittent blue light,group C was given continuous blue light irradiation. Seventy-two hours later, the clinical efficiency and the incidence of adverse reactions of two groups were compared.Results There was no obvious difference in treatment efficacy between the two groups after 72 hours irradiation（P0.05）.However,the adverse effects in group I were fewer than group C（P0.05）.Conclusion Intermittent blue light irradiation treatment can achieve the same therapeutic efficacy as continuous blue light irradiation treatment,but has fewer adverse reactions and is worthy of clinical application.