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细胞命运的逆转:体细胞核移植与诱导多能干细胞——2012年诺贝尔生理学或医学奖简介 被引量：1

Cell development backwards: somatic cell nucleus transfer and induced pluripotent stem cells——introduction of Nobel Prize in Physiology or Medicine 2012
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摘要 2012年诺贝尔生理学或医学奖分别颁发给来自英国的John B.Gurdon和日本的Shinya Yamanaka两位科学家,以表彰他们在"成熟细胞可重编程而具有多能性"方面的重大发现。他们开创性的工作改变了人们对于细胞或生物体发育程序的传统观念,促使人们去探寻逆转细胞发育命运的奥秘。 The 2012 Nobel Prize in Physiology or Medicine is awarded jointly to Dr. John B. Gurdon from United Kingdom and Dr. Shinya Yamanaka from Japan for their significant discovery that mature cells can be reprogrammed to become pluripotent. Their breakthrough findings have revolutionized the traditional view on the development program of cells or organisms, leading to an exploration on cell fate reversal.
作者 汪璇 王晓民
机构地区 首都医科大学神经生物学系
出处 《首都医科大学学报》 CAS 2012年第5期689-694,共6页 Journal of Capital Medical University
关键词 体细胞核移植 诱导多能干细胞 发育 重编程 诺贝尔生理学或医学奖 somatic cell nucleus transfer induced pluripotent stem cells development reprogramming Nobel Prize in Physiology orMedicine
分类号 R445.2 [医药卫生—影像医学与核医学]
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参考文献16

  • 1Gurdon J B. The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles [ J ]. J Embryol Exp Morphol, 1962, 10 : 622 - 640.
  • 2Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors [J]. Cell, 2006, 126(4): 663-676.
  • 3Frisrn J, Lendahl U, Perlmann T. Scientific background: mature cells can be reprogrammed to become pluripotent. The Official Web Site of the Nobel Prize. "The 2012 Nobel Prize in Physiology or Medicine-Advanced Information ". [EB/OL]. ( 2012-10-13 ). http ://www. nobelprize. org/no- bel_prizes/medicine/laureates/2012/advanced. html.
  • 4Briggs R, King T J. Transplantation of living nuclei from blastula ceils into enucleated frogs'eggs [ J ]. Proc Natl Acad Sci USA, 1952, 38(5) : 455 -463.
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  • 7Thomson J A, Itskovitz-Eldor J, Shapiro S S, et al. Embryonic stem cell lines derived from human blastocysts [ J ]. Science, 1998, 282(5391): 1145-1147.
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首都医科大学学报
2012年 第5期

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