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G蛋白偶联受体:药物发现的摇篮——2012年诺贝尔化学奖简介 被引量：2

G protein coupled receptor,the vault of drug discovery——introduction of Nobel Prize in Chemistry 2012
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摘要 2012年度的诺贝尔化学奖授予了在G蛋白偶联受体研究中作出突出成就的美国科学家罗伯特.莱夫科维茨(RobertJ.Lefkowitz)教授和布莱恩.克比尔卡(Brian K.Kobilka)教授。本文将对两位获奖者的研究工作与主要学术贡献给予较为系统的归纳和总结,并对其获奖工作的科学意义及在相关药物研发重点的应用和价值进行展望和分析。 Two American scientists Robert lefkowitz and Brian Kobilka have hunored the 2012 Nobel Price in Chemistry for their achievements in the G protein c, oupled receptor （GPCR） studies. In this article, we introduced their research in the related fields and summarized their major academic contribulions that recognized among scientific researchers. Furthermore, we expanded the discussion regarding the significance and the potential applications of their work for morden medication and drug development.
作者 张晨光 丁卫
机构地区 首都医科大学医学遗传学系
出处 《首都医科大学学报》 CAS 2012年第5期695-699,共5页 Journal of Capital Medical University
关键词 诺贝尔化学奖 G蛋白偶联受体 信号传递 药物研发 结构生物学 Nobel Prize in Chemistry G protein coupled reeeptor signal transduetion drug development structural biology
分类号 R962 [医药卫生—药理学]
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参考文献22

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同被引文献33

  • 1Hengstler JG,Bolt HM.Failure in drug development:the role of inhibition and induction of cytochrome P450enzymes[J].Arch Toxicol,2008,82(10):665.
  • 2Kola I.The state of innovation in drug development[J].Clin Pharmacol Ther,2008,83(2):227.
  • 3Morgan S,Grootendorst P,Lexchin J,et al.The cost of drug development:a systematic review[J].Health Policy,2011,100(1):174.
  • 4Nyigo VA,Malebo HM.Drug discovery and developments in developing countries:bottlenecks and way forward[J].Tanzan Health Res Bull,2005,7(3):154.
  • 5Swinney DC,Anthony J.How were new medicines discovered?[J].Nat Rev Drug Discov,2011,10(7):507.
  • 6Arrowswith J,Miller P.Trial watch:phaseⅡand phaseⅢattrition rates 2011-2012[J].Nat Rev Drug discov,2013,12(8):569.
  • 7Zerhouni E.Turning the titanic[J].Sci Transl Med,2014,6(221):221.
  • 8Chong CR,Sullivan DJ.New uses for old drugs[J].Nature,2007,448(7 154):645.
  • 9Yang L,Agarwal P.Systematic drug repositioning based on clinical side-effects[J].PLo S One,2011,6(12):e28 025.
  • 10Ghofrani HA,Osterloh IH,Grimminger F.Sildenafil:from angina to erectile dysfunction to pulmonary hypertension and beyond[J].Nat Rev Drug Discov,2006,5(8):689.

引证文献2

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首都医科大学学报
2012年 第5期

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