超敏C-反应蛋白、同型半胱氨酸和D-二聚体与脑梗死的关系

Relation between hs-CRP,Hcy and DD with cerebral infarction

目的观察超敏C-反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、D-二聚体(DD)与脑梗死的关系,并探讨三者的相关性。方法检测90例脑梗死患者血清hs-CRP、Hcy和DD的浓度,另外选择健康人群66例作为健康对照组。结果脑梗死患者中hs-CRP、Hcy和DD的浓度明显高于健康对照组(P<0.05)。且三者水平呈正相关(r分别为0.438、0.517、0.569,P值均小于0.05),相关性较好,敏感性高。结论 hs-CRP、Hcy、DD水平升高与脑梗死的发生有密切关系,联合检测有助于了解脑梗死患者的发生和病情变化,对脑梗死的预防、治疗和早期诊断有着积极的临床意义。

Objective To investigate the relation of high sensitivity C-reactive protein（hs-CRP）, homocysteine （Hcy） and D-dimers（DD） with cerebral infarction and the correlation among these 3 indexes. Methods The serum levels of hs-CRP, Hcy and DD were measured in 90 patients with cerebral infarction and 66 healthy controls. Results The concentration of hs-CRP, Hcy and DD in the patients with cerebral infarction was significantly higher than that in the normal control group（P^0.05）. And the levels of three indexes were positively correlated（r= 0. 438,0. 517 and 0. 569 ,P〈0.05）. The correlation was good with high sensitivity. Conclusion The levels of hs-CRP, Hcy and DD are closely related to the occurrence of cerebral infarction. The combined detection of hs-CRP, Hcy and DD is condu- cive to understand the occurrence of cerebral infarction and the change of disease condition, and has active clinical sig- nificance in the preventiort, treatment and prognosis of cerebral infarction.