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静脉输注不同剂量瑞芬太尼对大鼠热痛觉阈值的影响

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摘要 目的探讨静脉持续输注不同剂量瑞芬太尼对大鼠热痛觉阈值的影响,并观察其与剂量的关系。方法 40只健康雄性SD大鼠,建立颈静脉输液模型,随机分5组(n=8):R1、R2、R3、R4组分别通过颈外静脉持续输注瑞芬太尼0.3、0.6、1、1.5μg/(kg.min)共4 h,N组(对照组)输注生理盐水0.1 mL/(kg.min)。于建模前,建模后,给药后0.5、1、2、3、4 h(T1~T7)测量大鼠热痛觉阈值。结果颈静脉置管前后,大鼠热痛阈值比较差异无统计学意义(P>0.05);R3组和R4组,瑞芬太尼输注0.5 h时,大鼠热痛觉阈值达到最大值,之后开始降低,输注4 h时,大鼠热痛觉阈值分别降低为T3时点阈值的68%和61%(P<0.05);而R1组和R2组输注1 h时,热痛觉阈值达到最大值,输注4 h时,热痛觉阈值点较T3时点阈值分别下降了9%和13%,两者比较差异无统计学意义(P>0.05)。结论静脉持续输注瑞芬太尼小剂量不会出现耐受现象,随着剂量的增加易出现耐受现象,且与剂量呈正相关。
出处 《广东医学》 CAS CSCD 北大核心 2012年第20期3054-3056,共3页 Guangdong Medical Journal
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