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长期低剂量克拉霉素联合鼻用激素及鼻腔冲洗治疗复发性鼻窦炎的疗效 被引量:32

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摘要 目的观察长期小剂量克拉霉素联合鼻用激素及鼻腔冲光治疗复发性鼻窦炎的疗效。方法复发鼻窦炎术后的患者共45例,分为两组。克拉霉素组为克拉霉素片250 mg,2次/d,口服2周后改为250 mg,1次/d,共10周;糠酸莫米松鼻喷雾剂,每次2喷,1次/d,连续12周;生理盐水冲洗双侧鼻腔,1次/d,连续12周.鼻腔吸入组为糠酸莫米松鼻喷雾剂,每次2喷,1次/d,连续12周;生理盐水冲洗鼻腔,1次/d,连续12周。分别于治疗前与治疗后采用视觉模拟量表(visual analog scale,VAS)评估其症状,鼻内镜观察评估鼻腔。结果两组经过12周治疗后,其症状VAS总分和鼻内镜评分均较治疗前明显下降(P<0.05),两组间疗效差异有统计学意义(P<0.05),克拉霉素组治愈率显著高于鼻腔吸入组。结论长期小剂量克拉霉素联合鼻用激素及鼻腔冲洗较单纯应用鼻用激素和鼻腔冲洗治疗复发性鼻窦炎有着较好的疗效,可以明显改善患者症状。
出处 《广东医学》 CAS CSCD 北大核心 2012年第20期3159-3160,共2页 Guangdong Medical Journal
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参考文献8

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