温敏性水杨酸分子印迹水凝胶的合成与性能研究

Preparation and Properties of Temperature-responsive Molecularly Imprinted Polymer Hydrogels to Salicylic Acid

以水杨酸为模板分子,丙烯酰胺为功能单体,N-异丙基丙烯酰胺为温敏单体,乙二醇二甲基丙烯酸酯为交联剂,偶氮二异丁腈为引发剂,采用本体聚合法,60℃热聚合制备了温度敏感的分子印迹(MIP)水凝胶,其最低临界溶解温度(LCST)在40℃左右。该分子印迹水凝胶对水杨酸显示了高的选择识别性,非分子印迹水凝胶则表现出低的选择性。温敏性分子印迹水凝胶的吸附容量达6.35 mg/g,是非印迹水凝胶的3.66倍。相对于未添加温敏单体的分子印迹聚合物,温敏性水杨酸分子印迹水凝胶对目标分子的吸附和洗脱效率分别提高33.3%和50%,并实现了温度响应的水凝胶结合、释放水杨酸的功能。

A highly selective temperature-responsive molecularly imprinted polymer （MIP） hydrogel to salicylic acid （SA）was prepared by bulk polymerization at 60 °C, using salicylic acid as template molecule, aerylamide as functional monomer, N-isopropyl acrylamide as temperature-responsive monomer, ethylene glycol dimethaerylate as cross-linker, and azobisisobutyronitrile as the initiator. The lower critical solution temperature （LCST） of molecularly imprinted polymer hydrogels is about 40 °C. The temperature responsive molecularly imprinted polymer hydrogels showed good selectivity for SA, while non-imprinted hydrogels showed low selectivity, relative to those analogues of SA. The maximum adsorption capacity of the temperature-responsive molecularly imprinted polymer hydrogels reaches up to 6. 35 mg/g, which is 3.66 times for that of non-imprinted polymer hydrogels. Compared with the molecularly imprinted polymer without adding temperature-responsive monomers, the adsorption and elution efficiency of the MIP hydrogels with SA were increased by 33.3% and 50% , respectively. Moreover, the temperature-responsive hydrogels could absorb or release SA when the temperature was changed