我院2006～2010年住院患者抗生素不良反应分析

Analysis of Adverse Drug Reaction Induced by Antibiotic in Inpatients from 2006 to 2010

目的探讨抗生素致不良反应的发生情况,为临床规范、合理用药提供参考。方法对我院2006年2月至2010年12月住院患者上报的47例抗生素致不良反应病例,对患者的年龄、性别、不良反应史、用药途径、所用药物、不良反应临床表现等进行统计分析。结果抗生素致不良反应主要发生在41～60岁;β-内酰胺类抗生素致不良反应/事件最多;主要临床表现为皮肤过敏反应。结论医疗机构应重视抗生素引起的不良反应,加强抗生素的合理应用。

Objective To investigate the adverse drug reaction（ADR） induced by antibiotic, and provide advice for the safety and rational use of drugs. Methods To conduct a statistical analysis based upon the information from 47 inpatients with ADR which were reported from February 2006 to December 2010, such as age, gender, history of adverse reactions with drugs, route of administration, used drug, clinical manifestations, et al. Results ADR is likely to be reported in various ages section during inpatients, particularly those are 41-60 years old. The most adverse reactions were caused by beta-lactam antibiotics, and they mainly caused allergic skin reactions. Conclusion Medical institutions should pay attention to the antibiotic induced adverse reaction, and rational use of it.