丹黄通脉方对颈动脉粥样硬化性狭窄模型大鼠脑血流量的影响

The Effect of DanhuangTongMai Decoction on Cerebral Blood Flow in Carotid Atherosclerotic Model Rats

目的:研究丹黄通脉方(DHTMD)对颈动脉粥样硬化性狭窄模型大鼠脑血流量的影响。方法:采用高脂加高蛋氨酸复合饲料喂养联合颈总动脉球囊拉伤术建立大鼠颈动脉粥样硬化性狭窄模型,观察灌胃给药8周后,DHTMD对大鼠脑血流量的影响。结果:与空白组比较,模型组局部脑血流降低(P<0.05);与模型组比较,尼莫地平组和DHTMD组脑血流量增加(P<0.05);DHTMD组与尼莫地平组差异有无统计学意义(P>0.05)。结论:丹黄通脉方可以增加颈动脉粥样硬化性狭窄模型大鼠的脑血流量。

Objective： To study the effect of DanHuangTongMai Decoction（DHTMD） on cerebral blood flow in carotid atherosclerotic stenosis model rats. Methods： With feeding high fat and heightening methionine compound feed, after 4 weeks joint carotid artery balloon strain surgery to establish carotid artery atherosclerotic stenosis model rats. Using intragastric ad- ministration in 8 weeks, afterwards, determination of rats cerebral blood flow changes. Results： Compared with the control group, the regional cerebral blood flow of model group is reduced in model group （P〈0.05）, increased of nimodipine group and DHTMD group（P〈0.05）; DHTMD group compared with nimodipine group, there is no the statistically significant difference（P〉0.05）. Conclusion： DHTMD can increase cerebral blood flow of carotid atherosclerotic stenosis model rats.