养血固肾汤治疗老年肾虚型腰椎间盘突出症30例临床观察及免疫学分析

Clinical Observation and Immunology Analysis on 30 Cases with Elderly Kidney Deficiency Type Protrusion of Lumbar Intervertebral Disc Treated by Raise Blood Solid Renal Decoction

目的:探讨养血固肾汤治疗老年肾虚型腰椎间盘突出症的有效性和安全性并分析对免疫学炎症因子的影响。方法:将老年肾虚型腰椎间盘突出症的患者60例随机分为治疗组及对照组各30例,治疗组予养血固肾汤治疗,对照组予壮腰健肾丸治疗,比较两组的各阶段疗效、JOA、VAS评分及炎症因子(TNF-α、IL-6)的变化趋势。结果:总有效率治疗组为93.3%,对照组为80.0%,治疗组疗效优于对照组(P<0.05);治疗后治疗组的JOA评分结果显著高于对照组,VAS评分低于对照组,差异均有统计学意义(P<0.05);治疗组的细胞炎症因子TNF-α及IL-6下降幅度明显高于对照组,差异均具有统计学意义(P<0.05)。结论:养血固肾汤治疗老年肾虚型腰椎间盘突出症疗效较好,能改善患者的临床症状,降低体内免疫炎症因子TNF-α及IL-6的水平。

Objective： To study the efficacy and safety and analyzes immunology inflammation factor of Raise Blood Solid Renal Decoction on elderly kidney deficiency type protrusion of lumbar intervertebral disc. Methods： 60 cases of elder kidney empty type prolapse of lumbar intervertebral disc patients were randomly divided into treatment group （n=30） and control group（n=30）, respectively treated with Raise Blood Solid Renal Decoction and strong waist health renal pill. The stage curative effect, JOA score, VAS score and inflammatory factor （TNF-aand IL-6） were compared between the two groups. Results： The total effective rate of the treatment group was 93.3%, and the total effective rate of the control group was 80.0%; the treatment group showed better total effective rate than the control group （P〈0.05）. The JOA score of the treatment was higher than that of the control group after treatment （P〈0.05）; the VAS score of the treatment group was lower than that of the control group after treatment （P〈0.05）. The Decline rate of TNF-α and IL-6 in the treatment group was higher than that of the control group after treatment（P〈0.05）. Conclusion： Raise Blood Solid Renal Decoction can provide better effect on eider kidney deficiency type protrusion of lumbar intervertebral disc, relieve the symptoms and reduce the level of TNF-α and IL-6.