胃癌根治术保留迷走神经对术后急性炎症反应的影响研究

Clinical influence on postoperative acute inflammatory reaction of gastric carcinoma resection with preserving vagus

目的:通过胃癌患者术前与术后血清CRP、IL-1β、IL-6、TNF-α、α-AT的表达比较,探讨保留迷走神经对胃癌根治术术后急性炎症反应的影响。方法:应用酶联免疫吸附法(ELISA)检测74例胃癌患者术前和术后血清中的CRP、IL-1β、IL-6、TNF-α、α-AT蛋白含量。结果:胃癌根治术保留迷走神经组术后CRP、IL-6、TNF-α等种蛋白表达低于未保留迷走神经组(P<0.05),实验组术后平均最高体温低于对照组(P<0.05)。结论:保留迷走神经胃癌根治术术后血清CRP、IL-6、TNF-α蛋白水平显著降低,为保留迷走神经的胃癌根治术提供理论依据。

Objective： To retrospectively analyze the expressions of serum CRP,IL-1β,IL-6,TNF-αand α-AT pre and post operation and discuss the acute inflammatory reaction of the resection of gastric carcinoma with preserving vagus nerve.Methods： The serum of 74 patients was analyzed with ELISA.All cases were divided into two groups of gastrectomy with and without preserving vagus.Results： There was significant difference in serum levels of CRP、IL-6、TNF-α of post operation among the two groups.And postoperative maximum body temperature was different.Acute inflammatory reaction was lessened obviously in preserving vagus group（P〈0.05）.Conclusion： Vagotomy did influence acute inflammatory reaction after resection of gastric carcinoma.A cholinergic anti-inflammatory pathway mechanism for inflammatory reaction response including the reduction of fever is suggested which can contribute to the therapy of post gastrectomy