色甘酸钠、硝苯啶对致敏大鼠心脏及腹腔肥大细胞释放组胺的影响

The Effect of Disodium Cromoglycate and Nifedipine on the Released Histamine from Cells in the Rat Peritoneal Cavity and the Rat Heart

组胺是一种速发型变态反应的介质,具有广泛的生理活性。内源性组胺的大量释放是哮喘、气管炎和心律失常的主要诱因之一。体外心性变态反应引起组胺释放已有研究。

The pathological model in vivo of cardiac anaphylaxis in rats was established. The released histamine from the heart and peritoneal cavity of normal and sensitized rats was determined by HPLC. The results showed that the amount of released histamine, from the heart and peritoncal cavity of sensitized rats by challenging with antigen, was 2.39 and 3.51 times more than that of normal rats respectively. The histamine release was inhibited significantly by injection of 50 mg / kg disodium cromoglycate ⅳ and 120 mg / kg nifedipinc ip.