肺癌患者外周血循环DNA检测的研究进展
摘要
肺癌是世界上最常见的恶性肿瘤,其发病率和死亡率均居首位。肺癌是一种全身性疾病,很多患者在发现肺癌时已处于晚期,早期诊断和早期切除无疑能提高患者的治愈率和生存率。目前,还没有用于肺癌早期筛查的有效手段。随着外周血循环DNA的研究的不断深入,以血循环DNA检测作为肺癌早期筛查的手段逐步走进研究者的视野。
出处
《中华医学杂志》
CAS
CSCD
北大核心
2012年第39期2794-2797,共4页
National Medical Journal of China
基金
国家重点基础研究973发展计划(2011CB504300)
国家自然科学基金(30572130)
北京市自然科学基金(7102029)
参考文献35
-
1Tong YK, Lo YM. Diagnostic developments involving cell-free (circulating) nucleic acids. Clin Chim Acta, 2006, 363: 187- 196.
-
2Leon SA, Green A, Yaros M J, et al. Radioimmunoassay for nanogram quantities of DNA. J Immunol Methods, 1975, 9:157- 164.
-
3Fleischhacker M, Schmidt B. Circulating nucleic acids (CNAs) and cancer--a survey. Biochim Biophys Acta, 2007, 1775 : 181- 232.
-
4Gormally E, Caboux E, Vineis P, et al. Circulating free DNA in plasma or serum as biomarker of carcinogenesis : practical aspects and biological significance. Mutat Res, 2007, 635 : 105-117.
-
5Anker P, Mulcahy H, Chen XQ, et al. Detection of circulating tumour DNA in the blood ( plasma/serum ) of cancer patients. Cancer Metastasis Rev, 1999, 18:65-73.
-
6Van der Auwera I, Elst H J, Van Laere SJ, et al. The presence of circulating total DNA and methylated genes is associated with circulating tumour cells in blood from breast cancer patients. Br J Cancer, 2009, 100 : 1277-1286.
-
7Pathak AK, Bhutani M, Kumar S, et al. Circulating cell-free DNA in plasma/serum of lung cancer patients as a potential screening and prognostic tool. Clin Chem, 2006, 52:1833-1842.
-
8Xue X, Zhu YM, Woll PJ. Circulating DNA and lung cancer. Ann N Y Acad Sci, 2006, 1075 : 154-164.
-
9Paci M, Maramotti S, BeUesia E, et al. Circulating plasma DNA as diagnostic biomarker in non-small cell lung cancer. Lung Cancer, 2009, 64:92-97.
-
10Roth C, Kasimir-Bauer S, Pantel K, et al. Screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancer. Mol Oncol, 2011, 5:281-291.
-
1张保庆,辛英.肝脏转移瘤的CT诊断(附89例分析)[J].中国煤炭工业医学杂志,2002,5(1):71-72. 被引量:2
-
2吴光兴,卢军,丛树东.恶性黑色素瘤38例临床分析[J].肿瘤防治杂志,2005,12(16):1265-1266. 被引量:4
-
3章玉英.早期周围型肺癌的影像学诊断[J].基层医学论坛,2011,15(8):239-240. 被引量:2
-
4熊萍,蔡三军.哪些大肠息肉必须早期切除?[J].大众医学,2009(5):33-33.
-
5江太发.哪些大肠息肉必须早期切除[J].山西老年,2009,0(8):55-55.
-
6许凯,张旭,张军,傅斌,郎斌,吴振启,艾星,史涛坪.膀胱移行细胞癌患者外周血循环DNA死亡相关蛋白激酶的甲基化与纯合性缺失的研究[J].中华实验外科杂志,2008,25(3):404-404.
-
7张大江.肝癌基因治疗[J].临床放射学杂志,2002,21(9):731-734.
-
8戴菲,李亚珍,王丽娟.肝动脉化疗栓塞术及护理[J].吉林医学,2011,32(1):151-152. 被引量:1
-
9谢晶日,王美蓉,李明.基质金属蛋白酶-9与肝癌关系的研究进展[J].中西医结合肝病杂志,2011,21(1):62-64. 被引量:3
-
10冷梅,李琳,徐娅莎,邹艳君.周围型肺癌的CT诊断及分析[J].中国现代医药杂志,2007,9(12):123-124. 被引量:1