FeCl_3催化苯甲醛肟的合成研究

Synthesis of Benzaldehyde Oxime Catalyzed by Iron(Ⅲ) Chloride

以环境友好型FeCl3为催化剂,在CH3CH2OH/H2O溶剂中合成苯甲醛肟.研究了催化剂种类及其用量、反应温度、溶剂等因素对反应的影响,通过对产物进行GC-MS和NMR分析,得到了合成苯甲醛肟的最佳反应条件为:苯甲醛3mmol、盐酸羟胺6mmol,溶剂乙醇与水的体积比15:1,在0.5equiv FeCl3的催化下,反应回流20min后,产率达到91.1%.

Benzaldehyde oxime is synthesized with Iron （Ⅲ） Chloride as catalyst in CH3CH2OH/H2O solvent. Factors as the sorts and ammount of catalyst, reaction temperature, solvents are researched.The production is analyzed by GC-MS and NMR. The optium reaction is obtained as follows： benzaldehyde 3 mmol, hydroxylamine hydrochloride 6 mmol, alchohol and water （15：1）as solvent, 0.5 e- quiv FeC13, as catalyst and refluxed 20 rain with a yield.of 91.1%.