体外循环与胰岛细胞胰岛素抵抗

Cardiopulmonary bypass and insulin resistance of islet cells

背景心脏手术体外循环（cardiopulmonary bypass，CPB）可引起外周胰岛素抵抗（insulin resistance，IR）。CPB时间越长，IR程度越严重。目前国内外研究证实，胰岛α细胞和β细胞同样存在IR。但是有关CPB外周IR状态下胰岛细胞的分泌功能的研究甚少。目的针对CPB高血糖的研究现状，提出合理的研究方向，为更好地控制血糖水平提供理论依据。内容现就CPB和胰岛细胞IR的相关性作一综述。趋向胰岛细胞自身IR将在心脏手术血糖管理中得到进一步重视。

Background Cardiopulmonary bypass （CPB） can cause peripheral insulin resistance （IR）. The IR is more serious when CPB lasts longer. Currently, the studies have confirmed that IR can also exist in pancreatic islet beta（β） and alpha （α） cells. However, the studies about secretory function of islet cells during CPB are few so far. Objective To provide the basis for better control of blood glucose during CPB. Content This review will focus on the relationship of CPB and IR of islet cells. Trend Islet cells may produce their own IR, which will be paid more and more attention in blood glucose management during CPB in the future.