摘要
背景D-丝氨酸（D-sefine，D-Ser）是N-甲基-D-天冬氨酸（N-methyl-D-aspartate，NMDA）受体上甘氨酸位点的主要内源性配体，由胶质细胞及神经元合成和分泌，在体内经丝氨酸消旋酶（serine racemase，SR）的作用产生，可以被D型氨基酸氧化酶（D-amino acid oxidase，DAO）所代谢。慢性疼痛种类繁多，病因复杂。以往的研究证实，慢性疼痛涉及外周和脊髓水平的长期功能改变，导致中枢敏化的形成，NMDA受体在其中扮演了重要的角色。作为NMDA受体主要内源性配体的D-Ser，在慢性疼痛的发生发展过程中也起到了重要的作用。目的介绍D-Ser的生理功能及作用机制，了解其在慢性疼痛中的作用。内容结合国内外相关文献对D-Ser的新陈代谢、D-Ser在慢性疼痛中的作用及治疗价值进行阐述。趋向D-Ser调节系统为慢性疼痛的治疗提供了一个新的思路。
Background D-Serine（D-Ser） is a main endogenous modulator of N-methyl-D-aspartate（NMDA） receptor at the glycine binding site. It is synthesized and secreted by the glial cells and neurons. In vivo, it is synthesized via racemization of serine racemase and removed by D-amino acid oxidase （DAO）. There are many kinds of chronic pain, whose causes are complicated. Previous studies have confirmed that chronic pain is related to the long-term functional changes in peripheral and spinal levels, teading to the formation of central sensitization which NMDA receptor plays an important role in. D-Ser, a main endogenous ligand of NMDA receptor, is also important in the development and progression of chronic pain. Objective To understand the physiological function and mechanism of action of D-Ser, and its role in chronic pain. Content To review the recent advances of D-Set in chronic pain and the therapeutic value. Trend Regulatory system of D-Ser may provide a new way in the treatment of chronic pain.
出处
《国际麻醉学与复苏杂志》
CAS
2012年第11期773-776,共4页
International Journal of Anesthesiology and Resuscitation
