摘要
以单甲氧基聚乙二醇-外消旋聚乳酸为载体制备包载厚朴酚的纳米胶束新剂型,观察胶束的形貌,测定胶束的平均粒径、载药量、药物包封率及进行体外释药实验.研究表明,所制备的厚朴酚胶束呈规则球状,胶束平均粒径达纳米级,胶束的体外释药具有缓释特性.
The mPEG - PLA was applied as carder to encapsulate magnolol to form new dosage forms of nano - micelle. The shape of the nano - micelles were observed. The average size and the drug loading con - tent and encapsulation efficiency of the nano - micelles were determined. Solvent evaporation, the prepared magnolol micelles had nanosize and size distribution, they have excellent drug sustained- release behavior.
出处
《琼州学院学报》
2012年第5期22-25,共4页
Journal of Qiongzhou University
基金
海南省教育厅高等学校科研资助项目(Hj2009-132)
关键词
厚朴酚
胶束
体外释药
Magnolol
micelle
encapsulation efficiency
the drug loading
