灯盏花素联合美托洛尔对扩张型心肌病室性心律失常的疗效观察

Clinical efficacy of breviscapine plus metoprolol on ventricular arrhythmias in dilated cardiomyopathy patients

目的研究灯盏花素(Bre)联合美托洛尔对扩张型心肌病(DCM)室性心律失常的治疗作用。方法 139例扩张型心肌病均经超声心动图及X线心脏片确诊,按就诊顺序随机分为A、B两组,两组均常规使用美托洛尔及其他药物,A组另给灯盏花素胶囊或注射液50mg/d。定期来门诊随诊,共132例完成了至少3个月的用药。研究终点为用药3个月。结果灯盏花素联合美托洛尔治疗后患者,室性早搏、短阵室速的发生率明显减少,QTc间期缩短稳定。结论灯盏花素联合美托洛尔在稳定扩张型心肌病患者心肌电活动优于单用美托洛尔,能减少恶性室性心律失常的发生,改善预后。

Objective To study the clinical efficacy of breviscapine plus metoprolol on ventricular arrhythmias in dilated cardiomyopathy patients. Methods Patients were randomly divided into breviseapine plus metoprolol group（ A, n = 70） and metoprolol group（ B, n = 69 ） and all patients received conventional treatment. Group A received breviscapine （ 50mg/ d）. Patients were follow up for 3months at least. Results Breviseapine plus metoprolol can reduce premature ventrieular beats and non-sustained ventricular tachycardia and QTc can be shorten. Conclusions Breviscapine plus metoprolol use is superior to metoprolol alone for reducing ventricular arrhythmias in dilated cardiomyopathy patients.