40岁以下与40岁以上原发性肺癌的临床对比研究

Clinical comparative study of primary lung cancer in patients with aged less than 40 years andmore than 40 years

目的对比分析40岁以下与40岁以上原发性肺癌的临床特征。方法选择1999年1月至2007年1月经手术和病理确诊的原发性肺癌患者251例，按年龄分为两组，440岁组（27例），〉40岁组（224例），比较两组的临床特征，对两组临床数据进行统计学分析。结果40岁以下与40岁以上原发性肺癌相比，在性别、发病部位、肺外表现、影像学表现、纤维支气管镜、病理、分期、切除率及误诊率等方面比较差异有统计学意义（P〈0．05）；而5年生存率两组比较差异无统计学意义（P〉0．05）。结论40岁以下原发性肺癌有独特的病理特征，误诊率高，应引起足够重视，提高确诊率，尽平治疗以免延误病情。

Objective To comparatively analyze the clinicopathologic characteristics of primary lung cancer in patients with age less than 40 years and more than 40 years. Methods Two hundred and fifty-one patients with primary lung cancer diagnosed by operation and pathology from January 1999 to January 2007 were selected, including 27 cases with age ≤40 years and 224 cases with age 〉 40 years. The clinical characteristics were compaired between the two groups, and the clinical data were analyzed statistically. Results In gender, location, extrapulmonary manifestations, clinicopathology, clinical stage, resection rate and misdiagnosis rate, the differences between the two groups were significant （P 〈 0.05 ）. However, there was no significant difference in 5-year survival rate betwen the two groups （ P 〉 0.05 ）. Conclusions Lung cancer in patients with age less than 40 years has unique pathological fea- tures and high misdiagnosis rate. We should improve the diagnosis rate and avoid delaying the illness.