狼疮肾炎患者外周血白细胞介素-17、白细胞介素-18的表达及其与C3的相关性

Expression of IL-17 and IL-18 in the serum of patients with lupus nephritis and the relationship between them and C3

目的探讨狼疮肾炎患者外周血白细胞介素-17（IL—17）、白细胞介素-18（IL-18）的表达及其与补体3（C3）的相关性。方法将53例系统性红班狼疮（SLE）患者分为A组（非肾病的红班狼疮）23例和B组（狼疮肾炎）30例，另选取30例健康者为C组。测定血浆IL-17和IL—18，并测定SLE患者的C3。结果A、B两组IL-17和IL—18均较C组明显升高，并且B组IL-18较A组升高更显著（P〈0．05）；B组C3为（0．56±0．12）g／L，与IL—17呈负相关关系（r=-0．257，P〈0．05），与IL-18呈负相关关系（r=-0．138，P〈0．05）。结论外周血IL-17和IL-18均可反映SLE患者的病情活动情况，但在狼疮肾炎中IL-18更重要。

Objective To investigate the expression of interleukin-17（IL-17） and interleukin- 18 （IL-18） in the serum of patients with lupus nehritis and the relationship between them and C3. Meth- ods Fifty-three patients with systemic lupus erythematosus（SLE） were divided into two groups, 23 cases of non-nephritis SLE in group A and 30 cases of lupus nephritis in group B, and other thirty healthy peo- ple were enrolled in group C. The serum IL-17, IL-18 and C3 levels were detected. Results The IL-17 and IL-18 levels in group A and group B were higher than those in group C, and were higher in group B than those in group A （P 〈 O. 05）. The C3 level in group B was （0. 56 ＋0. 12）g/L, which had nega- tive correlation with IL-17 level （r = -0. 257, P 〈 O. 05） and IL-18 level （r = -0. 138, P 〈 0. 05）. Conclusions The 1L-17 and IL-18 levels in the serum of patients can reflect the activity of SLE, howev- er, IL-18 was more important in lupus nephritis.