单唾液酸神经节苷酯联合硫辛酸多靶点治疗老年2型糖尿病周围神经病变

Single sialic acid ganglioside combined with lipoic acid on elderly patients with type 2 diabetic peripheral neuropathy

目的对单唾液酸神经节苷酯联合硫辛酸多靶点治疗老年2型糖尿病周围神经病变的疗效进行分析。方法将80例老年2型糖尿病周围神经病变患者随机分为两组，对照组40例，治疗组40例。对照组在常规治疗的基础上加用弥可保，治疗组加用硫辛酸和单唾液酸神经节苷酯，两组疗程均为3周。治疗前后测正中神经、腓总神经的运动传导速度及感觉传导速度，并且测定患者血清C-反应蛋白浓度。结果治疗组总有效率为85．0％，对照组总有效率为67．5％，两组比较差异有统计学意义（P〈0．05）；治疗组治疗后正中神经、腓总神经的运动传导速度及感觉传导速度明显加快，优于对照组（P〈0．05）；治疗组C-反应蛋白降低程度明显优于对照组（P〈0．05）。结论单唾液酸神经节苷酯联合硫辛酸可以多靶点治疗老年2型糖尿病周围神经病变，值得临床推广。

Objective To analyze the effect of single sialic acid ganglioside combined with lipoic acid on elderly patients with type 2 diabetic peripheral neuropathy（DNP）. Methods Eighty elderly pa- tients with type 2 DNP were randomly divided into two groups, the control group（40 cases） and the treat-ment group （40 cases）. Patients in control group were treated with methycobal on the basisof conventional treatment, while patients in side combined with lipoic acid on the basis treatment group were treated with single sialic acid ganglio- of conventional treatment. They were treated for three weeks The motor conduction velocity （MCV） and sensory conduction velocity （SCV） of the median nerve and common peroneal nerve were detected before and after treatment. The C reactive protein（CRP） levels were also detected. Results The total efficiency rates were 85.0% in the treatment group and 67.5% in the control group, there was significant difference （P 〈 0. 05） . The MCV and SCV of ihe median nerve and common peroneal verve improved after treatment, while the treatment group was superior to the control group （P 〈 0. 05 ）. The CRP level of the treatment decreased more than that of the control group （P 〈 0.05）. Conclusions Single sialic acid ganglioside combined with lipoic acid is worthy of clinical application.