ST段抬高性心肌梗死患者急诊介入术中血栓抽吸对血小板活化因子的影响

Effect of thrombus-aspiration on platelet activating factor during emergency percutaneous coro- nary intervention in patients with acute ST segment elevation myocardial infarction

目的探讨急性sT段抬高性心肌梗死（STEMI）患者急诊介入术中血小板活化因子（PAF）与血栓抽吸的关系。方法选择2009年6月至2011年9月STEMI患者100例，其中急诊介入术（PCI）加血栓抽吸治疗者为血栓抽吸组（50例），同时期条件相当仅行急诊介入治疗患者作为标准PCI组（50例），比较两组的基础资料及PAF情况。结果两组术后PAF比术前明显升高（P〈0．05），且血栓抽吸组低于普通PCI组；在血栓负荷大的患者中PAF水平更高。结论STEMI急诊PCI术中血栓抽吸可以降低PAF水平，减少微小血管的血小板活化和聚集，改善梗死部位心肌水平的血液灌注。

Objective To investigate the relationship between thrombus-aspiration and platelet activating factor （PAF） during emergency percutaneous coronary intervention（PCI） in patients with acute ST segment elevation myocardial infarction（STEMI）. Methods One hundred STEMI patients underwent emergent PCI from June 2009 to September 2011 were choosed, 50 patients received thrombus aspiration were enrolled in study group, and 50 patients who only received routine PCI were enrolled in control group. The clinical data and the PAF levels were compared between the two groups. Results The PAF levels increased after PCI in both groups （P 〈 0. 05 ）. Compared with control group, patients in thrombus aspiration group had lower serum PAF level; The level of serum PAF was higher in the patients complicated with thrombus burden. Conclusions Thrombus-aspiration can lower the level of PAF, de- crease the platelet aggregation and activation in micro-vascular vessel and improve myocardium blood per- fusion in infarction area during emergency PCI in patients with STEMI.