急性大动脉粥样硬化性脑梗死患者S100B蛋白监测的临床意义

Detection of serum SIOOB protein in patients with acut atherosclerotic cerebral infarction

目的观察急性大动脉粥样硬化性脑梗死（AACI）患者血清S100B蛋白水平的变化。方法采用酶联免疫双抗体夹心法对95例住院的AACI组患者和正常健康组79例进行血清S100B蛋白水平的检测并进行比较，AACI组并按神经功能缺损程度评分（NFDS）分为轻型、中型、重型三组。结果AACI组的血清S100B蛋白水平显著高于正常健康组（P〈0．01）；血清S100B蛋白水平与急性脑梗死患者的神经功能缺损程度相关（P均〈0.05），病情越重S100B蛋白含量越高。结论S100B蛋白水平与AACI患者的病情严重程度相关，提示S100B蛋白水平持续升高者预后不良。

Objective To observe the changes of serum S100B protein levels in patients with acut atherosclerotic cerebral infarction （AACI）. Methods The levels of serum S100B protein in 95 patients with AACI and 79 normal controls were measured by double antibody enzyme-linked immunosorbent assays. Patients in AACI were subdivided into mild group, moderate group and severe group according to NFDS. Results The levels of serum S100B protein in patients with AACI were significantly higher than those in control group（ P 〈 0. 05）. The levels of serum S100B increased with the score of neurofunction detection increased. Conclusions S100B protein is related with the severity of AACI, and the increasing level of S100B protein indicating the poor prognosis.