笑气吸入镇静技术在胃镜检查中的应用价值

Application value of sedation technique with inhalation of nitrous oxide in gastroscopy

目的探讨笑气（N2O）吸入镇静技术在胃镜检查中的应用价值。方法将接受胃镜检查的620例患者随机分为两组：其中自愿接受笑气吸入镇静310例为笑气组，通过面罩吸入笑气浓度为45％～50％的笑氧混合气体；接受普通胃镜检查的310例为对照组。记录两组患者检查过程中不良反应的发生情况，监测检查前、检查中和检查后的血压、心率和血氧饱和度，胃镜检查后问卷调查患者的主观意见反应。结果笑气组患者呛咳、恶心、流涎、躁动和咽痛等不良反应较对照组明显减少（P〈0．01），对检查的满意度和愿意再次接受检查比例明显高于对照组（P均〈0．01）。两组患者的血压、心率、血氧饱和度相比较，差异均无统计学意义（P均〉0．05）。结论笑气吸入镇静技术应用于胃镜检查安全可行，能明显减少患者的痛苦和不良反应。

Objective To investigate the application value of sedation technique with inhalation of nitrous oxide in gastroscopy. Methods Six hundred and twenty patients underwent gastroscopy were randomly divided into two groups： nitrous oxide group （310 patients） and control group（310 patients）. In nitrous oxide group, mixed gas （45 % - 50% nitrous oxide and 50% - 55 % oxygen） was inhaled during gastroscopy. In control group, patients underwent conventional gastroscopy. Adverse reactions of all patients were observed. Blood pressure, heart rate and oxygen saturation were monitored before, during and after gastroscopy. Patients＇ self-feelings were recorded by questionnaire survey after gastroscopy. Results The incidences of adverse reactions such as cough, nausea, sialorrhea, agitation and angina decreased significantly（ P 〈0. 01 ）, the degree of satisfaction and proportiojn of re-acceptant gastroscopy increased significantly （ P 〈 0. 01 ） in nitrous oxide group to compared with control group. There was no significant difference in blood pressure, heart rate and oxygen saturation between the two groups （ P 〉0. 05）. Conclusions Sedation technique with inhalation of nitrous oxide in gastroscopy is safeand feasible. It could markedly reduce patients＇ discomfort and adverse reactions.