泌乳素腺瘤的影像表现和临床特点的相关研究

Study on the imaging manifestation and clinical characteristics of prolactinoma

目的探讨泌乳素腺瘤在不同性别患者中的影像特点,泌乳素水平,临床表现和治疗效果之间的关系。方法选择在我科手术治疗的84例(男23,女61)泌乳素腺瘤患者为研究对象,按照性别、肿瘤生长方式、血清泌乳素水平分类,与其临床表现和预后进行对比研究。结果男性患者中高泌乳素者(69.6%)明显多于女性(40.9%)。高泌乳素组中,男性患者均为广泛侵袭性生长的巨大腺瘤(100%)。女性高泌乳素组中,肿瘤大小与激素关系不明显而与生长方式相关。女性泌乳素腺瘤患者的治疗效果明显优于男性。结论垂体泌乳素腺瘤患者术前的激素水平、影像特点和肿瘤生长方式的综合评估对合理选择治疗方法、改善预后有着重要意义。

Objective To explore the relationship between the imaging characteristics,serum prolactin levels,clinical manifestation and the treatment outcome of patients with prolactinoma.Methods A total of 84 patients with prolactinoma admitted to our department were studied according to gender.The relationship between the clinical manifestations,endocrinology disorder,image characteristics and the treatment were compared and evaluated.ResultsHigh serum prolactin level was more observed in male patients（69.6%） than in female patients（40.9%）.Those patients with pituitary tumors invaded into the cavernous sinus usually presented a high level of prolactin in blood serum and it affected the outcome of the male patients.While the prolactin levels were related with the tuwor growth pattern,not the tumor size,in female patients.Conclusion The comprehensive evaluation of the prolactin level,the imaging characteristics and tumor growth manner are important for the choice of therapy and improving the treatment outcome of prolactinoma.