幽门螺杆菌感染与老年冠心病的相关性研究

Correlativity studies on helicobacter Pylori infection and coronary heart disease in old people

目的探讨幽门螺杆菌(HP)感染与老年冠心病的相关性以及可能机制。方法 173例老年冠心病患者,根据HP检测结果分成HP阳性组和HP阴性组,分析两组病人的冠心病患病率和血清生化检测指标的差别。结果①老年冠心病患者组HP感染阳性率高于正常对照组。②甘油三脂异常组HP感染阳性率明显高于正常组。③HP感染阳性组游离甲状腺素水平明显升高。结论①HP感染可能是老年冠心病的病因之一。②HP感染可增高甘油三脂水平,可能由此促使老年冠心病的发生发展。③老年冠心病组HP感染阳性者其血清游离甲状腺素水平增高,提示HP感染可能会促进甲亢的发生。

Objective Exploring the relationship between HP and coronary heart disease in old people.And the mechanism that HP may lead to atheroma.Methods 173 cases with coronary heart disease in old people were divided into two groups according to the results of HP：Positive HP group（n=65） and negative HP group（n=108）.The morbidities of coronary atherosclerotic heart disease and atherosclerotic cerebral infarction were detected.Results ①Positive rate of HP in CHD group is higher than the normal control group.②We found that the level of TG had statistical significance which indicated that there was realationship with HP.③There was statistical significance in the level of serum free thyroxine,It was indicated that there was some realationship with HP.Conclusion ① Infection of HP was possiblly one of the 1causes of CHD.②HP may promote the occurrence and development of CHD by increasing level of TG,influencing lipid metabolism and then triggering biochemistry cascade reaction.③HP may had some relationship with free thyroxine in CHD,and then promote the occurence of hyperthyreosis.