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产ESBLs革兰阴性杆菌中16S rRNA甲基化酶基因的检测

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摘要 产超广谱β-内酰胺酶（extended-spectrum β-lactamases,ESBLs）的革兰阴性杆菌是医院感染的重要病原菌,表现为多重耐药,给临床抗感染治疗带来了极大的困扰。近年来研究发现,一类由质粒介导的16SrRNA甲基化酶可使细菌的30S核糖体16SrRNA不与氨基糖苷类药物结合,从而导致细菌对氨基糖苷类药物出现高水平耐药,
作者 高辉 王杨 黄云昆 朱雯梅 徐敏
机构地区 昆明市延安医院检验科
出处 《中国实验诊断学》 2012年第10期1910-1912,共3页 Chinese Journal of Laboratory Diagnosis
关键词 16SRRNA甲基化酶 革兰阴性杆菌 ESBLS 产超广谱β-内酰胺酶 氨基糖苷类药物 酶基因 临床抗感染治疗 检测
分类号 R440 [医药卫生—诊断学]
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参考文献14

  • 1吴蓉,张隆,戴俊华,康向东.革兰阴性杆菌16S rRNA甲基化酶基因检测及作用研究[J].检验医学,2010,25(6):423-426. 被引量：7
  • 2刘晓莉,杨旭,单斌,杜廷义,黄云昆,吴肪.2002年昆明地区临床分离菌的耐药性监测及分析[J].中国抗感染化疗杂志,2004,4(4):202-205. 被引量：20
  • 3钟运华,何林,周克元,卢月梅.超广谱β-内酰胺酶研究进展[J].国际检验医学杂志,2008,29(3):252-254. 被引量：23
  • 4张玲,黄留玉.革兰阴性杆菌产超广谱β-内酰胺酶研究进展[J].中华医院感染学杂志,2008,18(6):897-900. 被引量：85
  • 5Varsha G. An update on newer β-lactamases[J]. Indian J Med Res,2007,11:417.
  • 6Galinland M, CourvMin P. Lambert T. Plasmid mediated high-level resistance to aminoglycosides in Enterobaeteriaceae due to 16S rRNA methylation[J]. Antimierob Agents Chemother,2003, 47:2565.
  • 7Yokoyama K, Doi Y, Yamane K, et al. Acquisition of 16S rRNA methylase gene in Pseudomonas aeruginosa[J]. Lancet, 2003,362:1888.
  • 8Yah JJ,Wu JJ,Ko WC,et al. Plasmid mediated 16S rRNA meth ylases conferring high-level aminoglycoside resistance in Esche richia coli and Klebriella pneumoniae isolates from two Taiwan Residents hospitals[J]. J Antimicrob Chemother, 2004,54 : 1007.
  • 9Wachino J, Yamane K, Shibayama K, et al. Novel plasmid-mediated 16S rRNA methylase,RmtC, found in a proteus mirabilis isolate demonstrating extraordinary high level resistance against various aminoglycosides[J]. Antimicrob Agents Chemother, 2006, 50(1) :178.
  • 10Yokoyama K,Doi Y,Yamane K,et al. Acquisition of 16S rRNA methylase gene in Pseudomonas aeruginosa [J]. Lancet, 2003, 362:1888.

二级参考文献57

  • 1潘韵峰,周华,俞云松.导致高水平氨基糖苷类抗生素耐药的新型16SrRNA甲基化酶研究进展[J].中华检验医学杂志,2007,30(6):699-701. 被引量：28
  • 2Medeiros AA. Evolution and dissemination of beta-lactamases accelerated by generations of beta-lactam antibiotics [J]. Ciin Infect Dis, 1997, 24 (Suppl 1): S19-S45.
  • 3Sturenburg E, Kuhn A, Mack D, et al. A novel extended-spectrum beta-lactamase CTX-M-23 with a P167T substitution in the active-site omega loop associated J Antimicrob Chemother, 2004, with ceftazidime resistance [J] 54(2): 406-409.
  • 4Kim J, Lim YM, Jeong YS, et al. Occurrence of CTX-M-3, CTX-M-15, CTX-M-14, and CTX-M-9 extended-spectrum beta-lactamases in Enterobacteriaceae clinical isolates in Korea[J]. Antimicrob Agents Chemother, 2005, 49(4): 1572-1575.
  • 5Hernandez JR, Martinez-Martinez L, Canton R, et al. Nationwide study of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum beta-lactamases in Spain [J]. Antimicrob Agents Chemother, 2005, 49(5): 2122-2125.
  • 6Mena A, Plasencia V, Garcia L, et al. Characterization of a large outbreak by CTX-M-1-producing Klebsiella pneumoniae and mechanisms leading to in vivo carbapenem resistance development [J]. J Clin Microbiol, 2006, 44(8): 2831-2837.
  • 7Mugnaioli C, Luzzaro F, De-Luca F,et al. CTX-M-type extended-spectrum beta-lactamases in Italy: molecular epidemiology of an emerging countrywide problem [J]. Antimicrob Agents Chemother, 2006, 50(8): 2700-2706.
  • 8Gniadkowski M, Schneider I, Palucha A, et al. Cefotaxime-resistant Enterobacteriaceae isolates from a hospital in Warsaw, Poland., identification of a new CTX-M-3 cefotaxime-hydrolyzing beta-lactamase that is closely related to the CTX-M-1/MEN-1 enzyme [J]. Antimicrob Agents Chemother, 1998, 42 (4) : 827- 832.
  • 9Yan JJ, Ko WC, Tsai SH, et al. Dissemination of CTX-M-3 and CMY-2 beta-lactamases among clinical isolates of Escherichia coli in southern Taiwan [J]. J Clin Microbiol, 2000, 38(12): 4320- 4325.
  • 10Yan JJ, Tsai SH, Chuang CL, et al. OXA-type beta-lactamases among extended-spectrum cephalosporin-resistant Pseudomonas aeruginosa isolates in a university hospital in southern Taiwan [J]. J Microbiol Immunol Infect, 2006, 39(2): 130-134.

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中国实验诊断学
2012年 第10期

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