E-cadherin和COX-2在大肠癌组织中的表达及其临床意义

Expression of E-cadherin and COX-2 in Large Intestinal Cancer Tissue, and Their Clinical Significance

为探讨上皮型钙黏蛋白（E-cadherin）和环氧化酶-2（COX-2）在大肠癌组织中的表达及其临床意义，本研究应用免疫组织化学EnVision法检测70例大肠癌组织及18例正常大肠组织中E-cadherin和COX-2的表达，并分析其与临床病理因素之间的相关性。结果显示，E-cadherin在大肠癌组织中的阳性表达率为58．57％（41／70），明显低于其在正常大肠组织中的阳性表达率88．89％（16／18），P＜O．05；COX-2在大肠癌组织中的阳性表达率为68．57％（48／70），明显高于其在正常大肠组织中的阳性表达率16．67％（3／18），P＜0．05。E-cadherin和COX-2在大肠癌组织中的表达与肿瘤浸润深度、分化程度、淋巴结转移情况相关，P＜0．05；与患者性别、年龄无关，P〉0．05。E-cadherin和COX-2在大肠癌组织中的表达呈负相关，r=0．28，P＜0．05。结果表明，E-cadherin和COX-2的表达与大肠癌的发生、发展、侵袭、转移密切相关，可作为大肠癌治疗及预后评估的重要指标。

This study was to investigate the expression of epithelial cadherin（E-cadherin） and cyclooxygenase-2（COX-2） in large intestinal cancer tissue, and their clinical significance. By using EnVision of immuno- histochemistry the expression of E-cadherin and COX-2 in 70 cancer tissue and 18 normal tissue were detected, and the correlation of expression and clinical pathological factors was analyzed. As results,the positivity expression rate of E-cadherin in cancer tissue was significantly lower than that in normal tissue[58.57% （41/70） vs 88.89% （16/18）, P〈0.05] ,while that of COX-2 in cancer tissue was significantly higher than that in normal tissue[68.57% （48/70） vs 16.67% （3/18）, P 〈0.05];And,the expression of E-cadherin and COX-2 in cancer tissue was related to the invasive depth, differentiation degree of neoplasms and lymph-node metastasis（ P〈0.05） ,while no relation with sex and age of patients（ P 〉0.05） ;E-cadherin expression in cancer tissue was correlated with COX-2 expression negatively（ r =-0.28, P 〈0. 05）. Results show that E-cadherin and COX-2 are closely related to occurrence, development,invasion and metastasis of large intestinal cancer,which could be important indicators for treating larger intestinal cancer and evaluating prognosis.