海南省7岁以下儿童及1～3岁儿童母亲麻疹抗体调查

Survey of measles antibody level in children under 7 years old and mothers of 1～3 year-old children in Hainan Province

目的了解海南省7岁以下儿童及1～3岁儿童母亲麻疹抗体水平,为海南省制定消除麻疹策略提供科学依据。方法2010年采取容量比例概率抽样(PPS)和系统抽样方法抽样,调查1～3岁儿童和小学一年级新生麻疹疫苗免疫史,同时采集被调查对象静脉血,检测麻疹IgG抗体,分析不同年龄组儿童麻疹IgG抗体水平差异、免疫史和抗体水平的关系。结果海南省2010年7岁以下儿童麻疹IgG抗体阳性率达95.7%;接种1针的抗体阳性率为94.1%,接种2针及以上者为97.4%,两者差异具有统计学意义(χ2=8.477,P<0.05)。各市县麻疹抗体阳性率均在92.5%以上;1～3岁和5～7岁两组儿童抗体阳性率分别为95.6%、96.1%,两组儿童差异无统计学意义(χ2=1.115,P>0.05);1～3岁儿童母亲抗体阳性率为98.1%。结论海南省7岁以下儿童麻疹IgG抗体维持在高水平,已经形成了牢固的保护屏障,有效控制麻疹病毒传播,为海南省2012年实现消除麻疹的目标奠定了极好的基础。

Objective To understand measles antibody levels in children under 7 years old and mothers of 1-3 year-old children in Hainan. Methods Capacity scale probability sample （PPS） sampling and system sampling method were employed to survey measles vaccination history of 1- 3 year-old children and pupils of first yearin primary school, at the same time sera samples were collected and separated to test IgG. Results The positive rate of measles IgG in children reached 95.7%. the positive rate of children with first-dose vaccination was 94.1% and 2 dose or above was 97.4%,the difference between them showed a statistical significance（x2=8.477,P=0.004 〈0. 05） .The positive rate in all counties was above 92.5%. The positive rates in 1-3 year- old and 3-7 year-old children were 95.6% and 96.1% , without significantly statistical significance. The positive rate in mothers of 1-3 year-old children was 98.1% and all above 90% in every counties. Conclusion The Measles antibody level in children under 7 years old has been maiantained at a high levelin Hainan province to have interrrupted the transmission of measles in this province.