2型糖尿病患者血浆前胰岛素水平

Proinsulin immunoreactivity (PIM)in type 2 diabetes mellitus

目的 :通过检测前胰岛素水平来探讨 2型糖尿病患者高胰岛素血症的原因。方法 :采用放射免疫分析法测定 2型糖尿病患者和正常对照组血浆前胰岛素 (PIM)、胰岛素 (IRI)和 C肽 (CP)水平。结果 :2型 DM组空腹 PIM(2 7.89± 2 2 .37pmol/ L)、IRI(186 .6 3± 136 .97pmol/ L)水平和 PM/ IRI比值 (17.11± 9.35 % )均明显高于对照组 PIM (6 .75± 5 .6 2 pmol/ L ) .IRI(10 7.6 7± 2 6 .43pm ol/ L )水平和 PIM/ IRI比值 (5 .6 7±3.6 6 % ) (P均 <0 .0 1) ;两组之间空腹 C P水平差异无显著性意义 (6 83.1± 5 87.4pm ol/ L比 5 2 8.0±2 0 1.3pm ol/ L,P>0 .0 5 )。结论 :2型糖尿病患者的高胰素血症主要是高前胰岛素血症所致 ,可能是胰岛素抵抗的原因之一。

Objective:To explore the causes of hyperinsulinemia in type 2 diabetes mellitus.Methods:Radio immune assay (RIA) was used to examine total proinsulin immunoreactivity (PIM), immune reactive insulin (IRI) and C peptide (CP) in patients with type 2 diabetes mellitus (DM) and control subjects.Results:Type 2 diabetic patients (DM vs.control subjects) had elevated fasting levels of total PIM (27.89±22.37vs.6.75±5.62pmol/L)、IRI(186.63±136.97vs. 107.67±26.43 pmol/L) and PIM/IRI (17.11±9.35% vs.5.67±3.66%) (all P<0.01). There was no significant difference of CP level between the above two groups (683.1±587.4 vs. 528.0±201.3 pmol/L, P>0.05).Conclusion:Hyperinsulinemia measured by RIA previously in type 2 DM could mainly due to hyperproinsulinemia and probably responsible for insulin resistance. [FK(WB80011。5]