精浆中催乳素浓度与精子活动力的关系及临床意义

Relationship between the concentrations of prolactin in seminal plasma and motility of the sperm and its clinical significance

目的 :探讨精浆中催乳素 (PRL)浓度与精子活动力和活动率的关系。方法 :选择不育症门诊中 6 0例男子进行精液分析 ,按精子活动力和活动率分成 A组 (活动力 ～ 级 ,活动率 >5 0 % )和 B组 (活动力 ～ 级、活动率≤5 0 % )。应用磁分离酶联方法测定其精浆中 PRL 浓度。结果 :A组精浆中 PRL 浓度为 (14.85± 4.0 5 ) μg/ L,B组为 (19.5 5± 4.85 ) μg/ L,A组与 B组之间 PRL 浓度差异有显著性 (P<0 .0 0 1)。精子活动力和活动率与精浆中 PRL 浓度呈负相关。结论 :血清和精浆中 PRL以不同方式进行调节 ,精浆中 PRL 来源于精囊 ,其浓度的高低影响着精子活动力和活动率。临床上不育症患者 ,采用分步射精法 ,摒弃后半部分精液 。

Objective:To study the relationship between the concentration of prolactin(PRL) in seminal plasma and the sperm motility Methods:60 infertile males in outpatient were divided into A and B groups according to sperm motility and viability(A group:motility degree Ⅲ～Ⅳ,viability rate>50%,B group,motility degree Ⅰ～Ⅱ,viability rate≤50%) Result:The concentration of PRL had significant difference between A group (14 85±4 05 μg/L)and B group (19 55±4 85 μg/L)( P< 0 001) There was negative correlation between sperm motility,viability and the concentration of PRL Conclusion:Sperm motility and viability are affected by the concentration of PRL,and split ejaculation method can be used to increase sperm activity and pregnancy rate