酸枣仁与黑胡椒的组方研究

Study of Prescription Composition of Ziziphi Spinosae Semen and Black Pepper

研究酸枣仁与黑胡椒不同配比及用量对改善睡眠作用的影响。酸枣仁水煎液喷雾干燥得到粉末与黑胡椒的细粉分别按药材量1∶5、1∶10、1∶15比例混合均匀后进行改善睡眠功能实验,筛选最佳配比;进而筛选最佳用量。3种配比均能延长戊巴比妥钠诱导的小鼠睡眠时间和缩短入睡潜伏期,以1∶10的比例混合效果更突出,按拟定剂量实验得到较好的效果。酸枣仁与黑胡椒的组方在改善睡眠方面其最佳配比为1∶10,在此基础上所拟定的剂量是适宜的。

To study the effects of different ratios and dosages of ziziphi spinosae semen and black pepper composing prescriptions on sleep improvement.To uniform mixing the spray drying powder of ziziphi spinosae semen extraction by water with the fine powder of black pepper at the different drug materiaes ratio 1∶5,1∶10,1∶15.Select the most appropriate proportion by using the mixture powder with different ratio to making experiments of sleeping improvement,then select the optimized dosage of the mixture.The time of sleep were prolonged and sleep latency were shortened in mice with the pentobarbital sodium induced by using the three different mixture.The effect of drug materiaes rate 1∶10 was the best.And good results were acquired with the drafted experiment dosage.The optimal drug materiaes rate of ziziphi spinosae semen and black pepper composing prescriptions on sleep improvemen was 1∶10.The dosage was appropriate to use on the basis.