液基薄层细胞学检测宫颈癌及癌前病变55221例临床分析

ThinPrep Cytology for Cervical Carcinoma and Precancerous Lesion Screening:An Analysis of 55 221 Cases

目的应用液基薄层细胞学技术结合伯塞斯达系统,探讨宫颈癌及癌前病变的发生与年龄的关系。方法对2006年1月至2011年12月在南昌大学第一附属医院妇科门诊行液基薄层细胞学技术检测55 221例资料进行回顾性分析,将伯塞斯达系统报告的意义不明确的非典型鳞状上皮细胞(ASCUS)以上病变列为阳性病例。结果 55 221例标本中,4 689例(8.49%)在正常范围内(WNL)、46 840例(84.82%)为良性反应改变(BCC)、1 956例(3.54%)为非典型鳞状上皮细胞(ASC)、1 014例(1.84%)为低级别鳞状上皮内病变(LSIL)、450例(0.81%)为高级别鳞状上皮内病变(HSIL)、147例(0.27%)为鳞状细胞癌(SCC)、103例(0.19%)为非典型腺上皮细胞(AGC)、22例(0.04%)腺癌(AC)。结论宫颈癌及癌前病变发病有年轻化趋势,TCT检测有助于预防宫颈癌及癌前病变的发病。

Objective To investigate the relationship of the occurrence of cervical cancer and precancerous lesions to age by using ThinPrep cytology test （TCT） and Bethesda system （TBS）. Methods A retrospective analysis was performed in 55 221 women who underwent TCT in gyne- cology clinic of the First Affiliated Hospital of Nanchang University from January 2006 to Decem- ber 2011. Atypical squamous cells of undetermined significance （ASC-US） or above of the cases were positive cases. Results Among the 55 221 specimens,4 689 （8.49%） were within normal limits（WNL） ,46 840 （84.82%） were benign reactive changes （BCC）,1 956 （3.54%） were ASC, 1 014 （1.84%） were low grade squamous intraepithelieal lesion （LSIL）,450 （0.81%） were high grade squamous intraepithelical lesion （HSIL）, 147 （0. 27%） were squamous ceil carcinoma （SCC）, 103 （0. 19%） were atypical glandular cells of undetermined significance （AGC）,and 22 （0.04%） were adenocarcinoma（AC）. Conclusion Cervical cancer and precancerous lesions tend to affect younger individuals. TCT can prevent the occurrence of cervical cancer and precancerous lesions.