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聚乙二醇-聚乳酸-聚谷氨酸苄酯共聚物的合成 被引量：3

Synthesis of Methoxypolyethylene Glycols-b-Poly [(Lactic Acid)-co-(γ-Benzyl L-Glutamate)]Copolymers
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摘要 利用乳酸和γ-谷氨酸苄酯分别合成了乳酸氧酸酐(LacOCA)和谷氨酸苄酯氮酸酐(BLG-NCA),然后在室温下用二甲氨基吡啶(DMAP)催化LacOCA、BLG-NCA和聚乙二醇单甲醚(MPEG)开环聚合,合成聚乙二醇-聚乳酸-聚谷氨酸苄酯的三元共聚物,用核磁、GPC等方法对共聚物进行了表征.该聚合物综合了聚醚、聚酯、聚氨基酸的性能,改善了聚氨基酸的溶解性.为聚酯-聚醚-聚氨基酸共聚物的合成提供一种新思路. Random copolymers of Methoxypolyethylene glycols - b - poly [ （ lactic acid） - co - （ y - benzyl L - glu- tamate） ] were obtained by ring - opening polymerization of L - lactic acid O - carboxyanhydride, amino acid - N - carboxyl anhydride with Methoxypolyethylene glycols in the presence of DMAP as an initiator. The structures of the copolymers were characterized with 1 H NMR, 13C NMR and GPC. Copolymerization improves the solvability of poly（ amino acid） in organic solvents. Additionally, it is a useful method to modulate the hydrophilie/hydrophobie and soft/hard properties of the copolymers by copolymerizing LacOCA with different monomers and oligomers.
作者 陈聪 贺正国 陈林 陈海云 袁明龙
机构地区 云南民族大学云南省聚乳酸基功能材料工程实验室
出处 《云南民族大学学报（自然科学版）》 CAS 2012年第6期399-403,共5页 Journal of Yunnan Minzu University:Natural Sciences Edition
基金 国家自然科学基金(31160198) 云南民族大学研究生创新项目(2011YCX06)
关键词 乳酸氧酸酐 谷氨酸苄酯氮酸酐 聚乙二醇单甲醚 共聚物 O - carboxylic anhydride of lactic acid N - carboxyanhydride of N - benzyl - L - glutamate methoxypolyethylene glycols copolymers
分类号 TQ050.4 [化学工程]
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参考文献16

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同被引文献47

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云南民族大学学报（自然科学版）
2012年 第6期

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