三维能量多普勒超声定量监测子痫前期胎盘血流灌注的临床价值

Assessment of placental vascularization in pre-eclampsia pregnancy by quantitative 3D power doppler ultrasonography

目的利用三维彩色能量多普勒超声成像(3D-CPA)结合其定量参数测定VOCAL功能,探讨3D-CPA对妊娠高血压综合征子痫前期患者胎盘内血流灌注显示情况、三维能量多普勒指数与二维彩色多普勒指数的相关性并评价其临床意义。方法采用GE公司Voluson 730三维超声成像系统的3D-CPA测量39例妊高征子痫前期及19例正常孕妇的胎儿胎盘的血管化指数(VI),血流指数(FI),血管化-血流指数(VFI),并与胎儿脐动脉S/D值、子宫动脉PI值以及胎儿大脑中动脉PI值比较分析。结果子痫前期患者胎儿胎盘的三维能量多普勒指数低于正常组且与脐动脉、子宫动脉、大脑中动脉血流指数相关。结论三维彩色能量多普勒超声成像(3D-CPA)技术是一项观察胎盘血流灌注的非常实用的方法。血管化指数(VI),血流指数(FI),血管化-血流指数(VFI)可直接反映子痫前期胎盘血流灌注情况,对了解胎盘功能及估计胎儿预后具有实际应用价值。

Objective To study the placenta perfusion in pre-eclampsia by three-dimensional power Doppler ultrasound and to evaluate its clinical importance.Methods 19 normal and 39 Pre-eclampsia Pregnancy women between 25 to 37 weeks were enrolled in this study.The vascularization index（VI）,flow index（FI）,and vascularization flow index（VFI）of the placenta were assessed by Quantitative 3D-CPA.Relationships among 3D placental flow indices and S/D in umbilical artery,PI in cerebral media artery along with uterus artery were evaluated by calculating their correlation coefficients.Results 3D Doppler indices of Pre-eclampsia Pregnancy are different from those of normal Pregnancy women.A significant correlation was observed between 3D Doppler indices and the other three color Doppler indices.Conclusion 3D-CPA technique is an important tool in routine evaluation of the placental vascular tree during gestation.The study of the3D Doppler indices was helpful to clinical diagnosis in the placenta function and fetus future of pre-eclampsia.