3种质子泵抑制剂根除幽门螺杆菌治疗消化性溃疡的成本-效果分析

Cost-effectiveness analysis of three kinds of proton pump inhibitors for treatment of peptic ulcer against helicobacter-pylori infection

目的对根除幽门螺杆菌治疗消化性溃疡的三种质子泵抑制剂进行药物经济学评价。方法查找并访问2011年1～8月的幽门螺杆菌感染的患者共152例,根据用药不同将其分为A,B,C组,分别是洛赛克+克拉霉素+阿莫西林、泮托拉唑+克拉霉素+阿莫西林、埃索美拉唑+克拉霉素+阿莫西林,疗程均为7～14d。疗程结束后,运用药物经济学的成本一效果分析方法对3组进行分析评价。结果 A、B、C组的成本分别是631.86元、630.70元、619.36元,幽门螺杆菌根除率分别为89.79%,90.19%和90.38%。治愈率为89.80%,、94.12%和94.23%。其成本效果比分别为5.58、5.32、5.21。结论埃索美拉唑治疗幽门螺杆菌感染的综合经济效益好,值得临床推广应用。

OBJECTIVE To evaluate the pharmacoeconomics outcomes of three kind of proton pump inhibitors for treatment of peptic ulcer against helicobacter-pylori infection.METHODS 150 patients helicobacter pylori infection were divided into A、B and C groups according to the different drug：omeprazole＋clarithromycin＋amoxicillin,pantoprazole＋clarithromycin＋amoxicillin,esomeprazolep＋clarithromycin＋amoxicillin.Use cost-effectiveness of analysis to evaluate three groups ofter 7～14days treatment.RESULTS The cost of A,B,C groups were 631.86yuan、630.70yuan and 619.36yuan.The eradication rates were 89.79%,90.19% and 90.38%.Cure rate was89.80%,94.12% and94.23%.The cost-effectiveness ratios were 5.58,5.32,5.21.CONCLUSION Esomeprazole is best of the three proton pump inhibitors to treat helicobacter pylori infection,it was worthy of clinical application.