两种术式治疗非肌层浸润性膀胱癌住院评价指标的Meta分析

目的比较经尿道钬激光切除术(HoLRBT)与电切术(TURBT)住院评价指标的优缺点。方法按文中所述纳入标准,检索国内外已公开发表的关于HoLRBT与TURBT治疗非肌层浸润性膀胱癌的比较性研究文献,并应用Reman5.0软件进行数据处理和分析。结果共有5个RCTs符合纳入标准,涉及总病例数914例,其中HoLRBT治疗548例。Meta分析结果提示在住院评价指标方面两组手术时间无显著差异(P=0.94),HoLRBT组的住院时间短(P<0.00001);术后膀胱冲洗例数少(P=0.004),尿管留置时间短(P<0.0001);HoLRBT组获得肿瘤分期例数多(P<0.00001)。结论钬激光是一种治疗非肌层浸润性膀胱癌高效安全的方法,在导尿管留置及住院时间、减少术后膀胱冲洗例数及获得肿瘤分期例数方面比电切术更优越。

Objective To compare the holmium laser resection（HoLRBT）and transurethral resection of bladder tumur（TURBT）in the treatment of Non muscle-invasive bladder Cancer with Hospital evaluation index.Methods According to the criteria in the paper,we retrieved published comparative studies on HoLRBT versus TURBT for Non muscle-invasive bladder Cancer.We completed a meta-analysis of publishedliterature.Results We found 5 randomized controlled trials.A total of 914 participants were in the trials,according to the eligibility criteria of 548 cases that were treated with HoLRBT.The Meta statistical showed as follow：there was no satistical difference between the two techniques in operation time（P=0.94）,the HoLRBT is more shorter in Hospital stay（P0.00001）,fewer in the numbers of postoperative bladder perfusion（P=0.004）,shorter in Catheter time（P0.0001）;HoLRBT obtained more case number of tumor stages（P0.00001）.Coclusion The HoLRBT technique is safe and effective for treatment of Non muscle-invasive bladder Cancer.In addition,HoLRBT had more advantages in the time of operation and Hospital stay,reducing the numbers of postoperative bladder perfusion and obtaining accurate tumor stage than TURBT.