阿托伐他汀在老年冠心病合并高脂血症中的临床应用

目的探讨阿托伐他汀在治疗老年冠心病合并高脂血症中的降脂效果以及临床应用的安全性。方法选取2010年7月～2011年10月期间住院的年龄大于65岁的冠心病患者260例为研究对象。将其随机分为观察组和对照组各130例,其中观察组口服阿托伐他汀钙40mg/d,对照组口服辛伐他汀20mg/d。3个月后检测并分析患者治疗前后的血脂水平及肝肾功能。结果治疗3个月后两组患者的血脂水平得到显著改善,与治疗前比较差异有统计学意义(t=1.835,2.914;P<0.05),观察组患者的改善情况更为明显(t=1.927,2.843;P<0.05)。观察组患者治疗前后肝肾功能差异无统计学意义(P>0.05)。结论阿托伐他汀40mg/d对老年冠心病合并高脂血症有明显的降脂作用,且对肝肾功能无显著的影响,是治疗高脂血症中安全、有效的方法之一。

Objective To study effect and the safety of clinical application of the atorvastatin in the treatment of elderly coronary heart disease combine with hyperlipidemia.Methods In our hospital in July 2010～2011 during the October in older than 65 years of age 260 cases of patients with coronary artery disease was as research object.The patients were randomly divided into observation group（given oral--atorvastatin calcium statins 40 mg/d）,and the control group（given oral simvastatin 20 mg/d）.Three months after treatment,lipid levels and liver and kidney function were analyzed.Results Lipid levels in two groups improved dramatically,there was significant difference before and after treatment（t=1.835,2.914;P0.05）.But the observation group improved obviously（t=1.927,2.843;P0.05）.Liver and kidney function in the observation group had no significant difference before and after treatment（P0.05）.Conclusion Atorvastatin 40 mg/d for the elderly with coronary heart disease and hyperlipidemia can lower the level of cholesterol,and has no significant side effects on liver and kidney function,is the safe and effective method to treat hyperlipemia.