多民族呼吸道、消化道肿瘤凝血功能相关指标的临床对照研究

Clinical study of dysfunction of blood coagulation in patients of multiple nationalities with respiratory and digestive tract malignant tumors

目的探讨呼吸道、消化道恶性肿瘤患者凝血功能相关指标的变化及不同部位肿瘤对凝血功能的影响。方法定量检测对照组(40例)、呼吸道肿瘤组(40例)、消化道肿瘤组(40例)患者的血小板(PLT)计数、血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、血浆纤维蛋白原(FIB)和D-二聚体(D-D)含量并进行对比分析,同时进行组间差异性比较。结果呼吸道肿瘤组PLT、PT、APTT、TT、FIB及D-D含量均高于正常对照组,消化道肿瘤组PT、FIB、APTT及D-D含量高于对照组,呼吸道肿瘤组FIB高于消化道肿瘤组,差异均有统计学意义(P<0.05)。结论呼吸道及消化道恶性实体瘤患者均存在明显的凝血功能异常;恶性实体瘤凝血功能异常可能与肿瘤的原发部位无关,与肿瘤细胞自身对凝血系统的影响有关。

Objective To study the level of blood clotting indexes in respiratory and digestive tract malignant tumors,and to investigate the influence in different locations.Methods The levels of platelet count（PLT）,prothrombin time（PT）,activated partial thromboplastin time（APTT）,thrombin time（TT）,plasmatic fibrinogen（FIB） and D-dimmer content（D-D） were tested in the blood samples in 40 respiratory tumor patients（respiratory tumor group）,40 digestive tract tumor patients（digestive tract tumor group） and 40 healthy people（control group）,analyzed the differences among those groups.Results： The levels of plasma PLT,PT,APTT,TT,FIB and D-D in respiratory tumor group were significantly higher than the control group（P0.05）.The levels of plasma PT,FIB,APTT and D-D in digestive tract tumor group were significantly higher than the control group（P0.05）.The levels of plasma FIB in respiratory tumor group were significantly higher than the digestive tract patients（P0.05）.Conclusion Respiratory and digestive tract malignant tumor patients were abviously manifested abnormal in coagulant function.There seemes no ralationship between the abnormality in coagulant function and the primary location of the malignant tumors.Malignant tumor patients may irrelevate with tumor primary site.