石榴皮鞣质对糖尿病大鼠血脂的影响及对肝脏的保护作用

Effects of Tannin in Punica granatum L. on Blood Lipids and Its Protecting Liver Ability in Diabetic Rats

目的初步观察石榴皮鞣质对糖尿病大鼠血脂的影响及肝脏的保护作用。方法采用腹腔注射链脲佐菌素(75mg/kg)的方法建立糖尿病大鼠模型,将成模大鼠随机分为4组:模型组、石榴皮鞣质低、中、高剂量组,另取正常大鼠作为空白对照组。连续给药21天后,观察石榴皮鞣质对血糖血脂和肝功能的影响。结果与模型组比较,石榴皮鞣质可显著降低GLU、TG、TC、LDL-C浓度、ALT活性(P<0.05,P<0.01),提高HDL-C浓度(P<0.05,P<0.01)。结论石榴皮鞣质对糖尿病大鼠的肝脏具有保护作用,可降低血糖调节血脂。

Objective To study the effects of Tannin in Punica granatum L. on blood lipids and its protecting liver ability in diabetic rats. Methods Diabetic rat models were induced by i.p. injection of streptozotocin （75mg/kg）. The diabetic rats were randomly divid- ed into four groups：model group, tannin in punica granatum L. 50, 75, 100mg/kg treatment Group. The blank control group was com- posed by normal rats. Serum alanine transaminase（ALT） activity of rats in each group, and glucose （GLU） ,triglyceride（TG） ,total cho- lesterol（TC） , high density lipoprotein - cholesterol （HDL - C ） , low density lipoprotein - cholesterol （LDL - C ） levels were studied 21 days after medication administration. Results Compared with model Group, Tannin in punica granatum L. can lower GLU,TG,TC,LDL - C concentration and ALT activity significantly （ P 〈 0.05,P 〈 0.01 ）, increase HDL - C levels （ P 〈 0.05, P 〈 0.01 ）. Conclusion Tannin in punica granatum L. has the function of good protection in liver of diabetic rats, It can lower blood glucose and regulate blood lipids.