摘要
HSP70作为热休克蛋白家族中最重要一类,具有分子伴侣作用,并在抗原递呈、交叉递呈、激活淋巴细胞、自然杀伤细胞、巨噬细胞以及诱导树突状细胞成熟中发挥重要作用,参与机体特异性免疫和固有免疫,在胃癌组织中高表达。HSP70可能通过与多种原癌基因和抑癌基因及其蛋白产物相互作用从而调节肿瘤细胞的增殖。HSP70增高与胃癌发生、发展及浸润与淋巴结转移有密切关系。利用HSP70的反义基因可以抑制HSP70在胃癌组织的高表达,对阻碍胃癌的发生具有重要的作用。
As one of the most important class in the heat shock protein family, HSP70 has a molecular chaperone role, HSP70 play an important role in antigen presenting, cross-presenting, activated lymphocytes, natural killer cells, macrophages, and induce dendritic cell maturation. It participates in the body specific immunity and innate immunity, and high expression in gastric carcinoma. HSP70 may be interacting with many kinds of proto-oncogenes and tumor suppressor genes and their protein products to regulate the proliferation of tumor cells. HSP70 increased is closely related with gastric cancer development, invasion and lymph node metastasis. Use of HSP70 antisense gene can inhibit the expression of HSPT0 in gastric cancer and to hinder the occurrence of gastric cancer has an important role.
出处
《疾病监测与控制》
2012年第11期672-673,668,共3页
Journal of Diseases Monitor and Control
关键词
HSP70
胃癌
HSP70
gastric carcinoma
