摘要
目的研究比索洛尔治疗原发性高血压的有效性及安全性。方法应用Meta分析对11篇文献研究中比索洛尔与其他常用抗高血压药治疗原发性高血压的有效性、安全性进行同质性检验及合并效应量的估计。结果同质性检验的有效性:χ2=9.3473,df=10;安全性:χ2=4.0549,df=10;P>0.05。合并效应量的估计:有效性:OR合并95%可信区间为1.53～3.06。安全性:OR合并的检验:χ2=19.592 9,P<0.001。结论比索洛尔治疗原发性高血压的疗效总体上优于目前其他药物,而且安全性比较无显著性差异。
Objective To evaluate the safety and efficiency of bisoprolol in treatment of essential hypertension.Methods The homogeneity test and merging effect value estimation on the efficacy and safety of Bisoprolol and other antihypertensive drugs in the treatment of essential hypertension were carried out using Meta-analysis,which was reported in 11 research papers.Results Homogeneity test showed that the cited studies of efficacy and safety were homogenous： χ2= 9.3473（df = 10） and χ2= 4.0549（df = 10）（P 0.05）.The results of merging effect value estimation were as follows： 95% confidence interval of ORmergingwas 1.53—3.06.The result of ORmergingtest was χ2= 19.592 9,P 0.001.Conclusion The effect of Bisoprolol on essential hypertension is better than that of other drugs,in addition,the safty has no significant difference between Bisoprolol and other drugs.
出处
《药物评价研究》
CAS
2012年第5期365-368,共4页
Drug Evaluation Research
