桂枝巴戟天黄芪颗粒对衰老大鼠免疫功能及骨生物力学的影响

The effects of Rumulus-Morinda-Milkvetch Granules on the Immune Function and Bone Biomechanics of Senile rats

目的:评价桂枝巴戟天黄芪颗粒对衰老大鼠免疫功能及骨生物力学的影响。方法:50只雄性SD大鼠,随机分为空白对照组,模型组、桂枝巴戟天黄芪颗粒高、中、低剂量组。均采用D-半乳糖连续腹腔注射制作衰老大鼠模型。在大鼠造模成功后分组灌胃,每天1次,给药30d后,检测迟发性变态反应、血清溶血素、血清中白介素2(IL-2)的含量及大鼠右侧股骨最大载荷和最大挠度。结果:桂枝巴戟天黄芪颗粒能增高衰老大鼠迟发性变态反应中耳肿胀度、血清溶血素及血清中IL-2含量,能增高模型大鼠股骨最大载荷、最大挠度。结论:桂枝巴戟天黄芪颗粒能增强衰老大鼠的免疫功能,改善衰老大鼠骨生物力学性能,有抗衰老的作用。

Objective：To evaluate the effects of Ramulus Cinnamomi - Morinda- Milkvetch （RMM） granules on the immune function and bone biomechanics of senile rats. Methods： Fifty SD rates were randomly divided into control group, model group, high, middle and low-dose-RMM groups. All the models were administered D-galactose intraperitoneally. After successful modeling, all the rats were lavaged daily for 30 days in total. Then delayed hypersensitivity reaction, serum hae molysin, IL-2, the maximum load and the maximum deflection of the right lateral femurs were tested. Results：RMM gran ules increased the extent of the swelling of the ear, serum haemolysin, the content of IL-2, the maximum load and the max imum deflection of the right lateral femurs. Conclusion-. RMM granules can strengthen the immune function and bone bio mechanics of senile rats and have anti-aging effects.