盐酸吉西他滨的合成路线图解

Graphical synthetic routes of gemcitabine hydrochloride

吉西他滨具有抗瘤谱广、毒副反应低等特点,被广泛应用于各种实体肿瘤的治疗,尤其是对胰腺癌和非小细胞肺癌有显著的疗效。公开报道的吉西他滨的合成路线多且杂,因此,很有必要将其合成路线进行归纳整理,方便人们查阅以及做出相应的工艺优化。

Gemcitabine,which has wide anti -tumor spectrum and little side -effects, is widely used in the treatment of solid tumors, especially pancreatic cancer and non - small cell lung cancer. The synthesis routes of gemcitabine were miscellaneous. Therefore, it was necessary to analyze the synthetic routes for its convenient consulting and further optimization.