脂质组学在中医证的生物学基础研究中的优势探讨

Advantages of biological basic study of lipid genomics in syndrome of traditional Chinese medicine

证是中医认识诊断疾病,据此遣方用药和观察疗效的基础,证候诊断及疗效评价的客观化与标准化研究对实现中医药现代化至关重要。脂质组学是对整体脂质进行系统分析的一门新兴学科,通过比较不同生理状态下脂代谢网络的变化,进而识别代谢调控中关键的脂生物标志物,最终揭示脂质在各种生命活动中的作用机制。中医的整体观及系统理论与脂质组学的系统研究不谋而合,随着质谱技术的进步,脂质组学在中医证本质研究、证候脂生物标志物的识别、证候诊断、药物作用机制的研究等方面已展现出广泛的应用前景。

Syndrome is the basis of TCM（traditional Chinese medicine） understanding and diagnosing disease,herbal prescription and observing effect.Syndrome diagnosis and clinical evaluation of the objective and standardized research is crucial to modernization of Chinese medicine.Lipid genomics is an emerging discipline that systematically analyze overall lipid and then identify the key lipid biomarkers of metabolic regulation by comparing lipid metabolism changes in the network under different physiological states to finally reveal the mechanism of action of the lipids in a variety of life activities.The holistic view and system theory of Chinese medicine coincide with the systematical study of lipid group.With the advances of mass spectrometry technology,study of lipid genomics in research of TCM syndrome essence,identification of lipid biomarker of syndrome,syndrome diagnosis and study of mechanism of drug action has demonstrated the broad application prospects.