六味地黄汤治疗2型糖尿病肾阴虚证与非肾阴虚证的临床实验研究

Clinical and experimental study of Liuweidihuang Decoction in treating type 2 diabetes mellitus with kidney yin deficiency syndrome and non kidney yin deficiency syndrome

目的:探讨六味地黄汤治疗2型糖尿病肾阴虚证与非肾阴虚证的疗效及与神经内分泌免疫(NEI)网络调节的相关性。方法:选择2型糖尿病患者80例,其中肾阴虚证组和非肾阴虚证组各40例;在肾阴虚证组和非肾阴虚证组内随机分配为实验组及对照组各20例;实验组给予六味地黄汤煎剂口服,对照组给予优降糖口服,疗程4周;观察临床症状、糖尿病疗效指标和NEI网络变化。结果:六味地黄汤对肾阴虚证和非肾阴虚证的2型糖尿病患者的NEI网络调节均有影响,但对肾阴虚证组的影响较大;六味地黄汤对2型糖尿病肾阴虚证组患者的综合疗效、降低血糖的效果均优于西药对照组和非肾阴虚证的实验组。结论:六味地黄汤所适用的糖尿病病证主要是肾阴虚证;六味地黄汤通过多靶点作用于NEI网络调节进而对不同疾病的"肾阴虚证"发挥治疗作用可能是其"异病同治"的关键所在。

Objective： To explore the treatment effect of Liuweidihuang Decoction on type 2 diabetes mellitus with kidney yin deficiency syndrome and non kidney yin deficiency syndrome and to discuss the correlation of Liuweidihuang Decoction and Neuro-endocrine-immunity network（NEI）.Methods： 80 patients with type 2 diabetes mellitus were divided into kidney yin deficiency group（40 patients） and non kidney yin deficiency group（40 patients）.Each group were randomly divided into treatment group and control group（20 patients）.The patients of treatment group were given Liuweidihuang Decoction.The patients of control group were given glybenzcyclamide.4 weeks is a treatment course.Clinical symptoms,diabetes indicators and the change in NEI network were observed before and after treatment in both groups.Results： Liuweidihuang Decoction has an effect on NEI network of type 2 diabetes mellitus patients,both in kidney yin deficiency group and non kidney yin deficiency group,but greater in kidney yin deficiency group.Comprehensive effect and the reduce of blood glucose is superior to the control group and non kidney yin deficiency group.Conclusion：Liuweidihuang Decoction is mainly for kidney yin deficiency syndrome of type 2diabetes mellitus.The key point of Liuweidihuang Decoction treating kidney yin deficiency syndrome of different diseases maybe lies in it,regulating NEI network through multiple targets.