相溶解度法研究不同环糊精对丹皮酚的增溶作用

Enhanced solubility of paeonolum with different types of cyclodextrins by phase solubility method

采用相溶解度法,通过测定丹皮酚在不同温度不同浓度的β-环糊精(β-CD)、羟丙基-β-环糊精(HP-β-CD)、羟乙基-β-环糊精(HE-β-CD)、取代度为4的磺丁基醚-β-环糊精(SBE4-β-CD)以及取代度为7的磺丁基醚-β-环糊精(SBE7-β-CD)中的溶解度,绘制相溶解度曲线,丹皮酚的溶解度均随5种环糊精浓度的增加而成线性增加,相溶解度曲线为AL型,说明丹皮酚与环糊精以1∶1包合,实验结果表明,5种环糊精对丹皮酚均有增溶作用且SBE7-β-CD的增溶效果最佳.

The phase solubility curves of paeonolum（PAE） were obtained by determining the solubility of paeonolum in different concent rations of β-CD and it＇s derivatives（HP-β-CD、HE-β-CD、SBE4-β-CD and SBE7-β-CD at different temperatures.The experimental results indicated that the phase solubility curves of paeonolum in five different cyclodextrins were AL styles and the inclusion ratio of paeonolum versus cyclodextrins was 1∶1.PAE solubility in the water can be improved by introducing CD derivatives into the system.The best enhancing effect of paeonolum solubility was SBE7-β-CD.