二仙汤加密蒙花配方颗粒治疗更年期干眼症86例临床观察

Observation of Erxian Decoction plus Buddleja offiginalis on 86 climacteric women with dry eye syndrome

目的评价二仙汤治疗更年期干眼症的疗效。方法更年期干眼症患者86例172只眼,予二仙汤加密蒙花的颗粒剂治疗。观察临床疗效及泪液分泌试验(Schirmer I test,SIt)、泪膜破裂时间(tear break-uptime,BUT)变化。结果 86例患者中,显效64例,占74.4%,有效13例,占15.1%,无效9例占10.5%,总有效率为89.5%。治疗前SIt值为(6.1±2.7)mm/5 min,3个疗程结束时为(8.2±2.2)mm/5 min,前后差异有统计学意义(t=1.989,P=0.03)。治疗前BUT值为(3.6±1.3)s,3个疗程结束时为(6.6±3.5)s,前后差异有统计学意义(t=1.988,P=0.03)。结论二仙汤加密蒙花的颗粒剂治疗更年期干眼症有较好疗效。

OBJECTIVE To evaluate the curative effect of Erxian Decoction for the treatment of climacteric dry eye syndrome,and explore the ideal method in treating dry eye syndrome.METHODS Eight-six climacteric dry eye syndrome patients（172 eyes） were treated by Erxian Decoction plus Buddleja offigindisd and the changes of ocular surface determination of tear secretion（schemer test）,tear film rupture of time（BUT method） before and after treatment were observed.RESULTS The remarkable effective rate was 74.4%（64 cases）,effective rate was 15.1%（13 cases）,none effective rate was 10.5%（9 cases）,and the total effective rate was 89.5%.Before treatment SIt was（6.1±2.7） mm/5 min,after treatment SIt（8.2±2.2） mm/5 min,before treatment BUT（3.6±1.3） s,after treatment BUT（6.6±3.5） s.CONCLUSIONS The Erxian Decoction plus Buddleja offigindis for the treatment of dry eye syndrome in Climacteric Women had remarkable effect.