低蛋白饮食联合α-酮酸对以轻度蛋白尿为主的原发性肾小球肾炎预后临床研究

Clinical Study of Low-protein Diet Combined with α-keto Acid on the Prognosis of Primary Glomerulonephritis with Mild Proteinuria

目的:初步探讨低蛋白饮食联合α-酮酸能否改善以轻度蛋白尿为主的原发性肾小球肾炎患者的临床意义。方法:40例以轻度蛋白尿为主的原发性肾小球肾炎患者分为治疗组和对照组,其中治疗组20例,接受低蛋白饮食联合α-酮酸和常规治疗;对照组20例,接受低蛋白饮食和常规治疗。观察两组患者尿蛋白量下降、蛋白尿转阴率及中等量以上蛋白尿率。结果:(1)两组病例入选时基线资料可比性好(P>0.05);(2)在现有条件下失访率不超过5%;(3)治疗组尿蛋白量显著减少[(0.45±0.23)g/24hvs.(0.91±0.35)g/24h,P<0.05)];中等量蛋白尿终点事件发生率显著低(P<0.05)。结论:低蛋白饮食联合α-酮酸能改善以轻度蛋白尿为主的原发性肾小球肾炎的尿蛋白量。

Objective ：To investigate whether low - protein diet combined with α - keto acid can improve the prognosis of primary glomerulonephritis with mild proteinuriao Methods：40 patients were randomly assigned to treatment and control groups. Treatment group（20 cases） received low -protein diet combined with α -keto acid and conventional treatment; control group（20 cases） received alow protein diet and conventional treatment. The primary efficacy judgment indicators： （1） the amount of urinary protein ; （2） the rate of proteinuria was negative and moderate amount of proteinuria. Results： （ 1 ） Baseline data were comparable in the two groups （P 〉 0.05） ; （2） Under existing conditions, the dropout rate does not exceed 5 % ; （3） urinary protein of treatment group significantly reduced [ （0.45 ± 0.23 ） g/24 h vs. （0.91 ± 0.35 ） g/24 h, P 〈 0.05 ） ; moderate amount of proteinuria endpoint events were significantly low （ P 〈 0.05 ）. Conclusion： The study shown that low - protein diet combined with α - keto acid can reduce urinary protein of primary glomenrulonephritis with mild proteinuria.